Explore the Potential with AI-Driven Innovation
This comprehensive focused library is produced on demand with state-of-the-art virtual screening and parameter assessment technology driven by Receptor.AI drug discovery platform. This approach outperforms traditional methods and provides higher-quality compounds with superior activity, selectivity and safety.
We carefully select specific compounds from a vast collection of over 60 billion molecules in virtual chemical space. Our partner Reaxense helps in synthesizing and delivering these compounds.
In the library, a selection of top modulators is provided, each marked with 38 ADME-Tox and 32 parameters related to physicochemical properties and drug-likeness. Also, every compound comes with its best docking poses, affinity scores, and activity scores, providing a comprehensive overview.
We use our state-of-the-art dedicated workflow for designing focused libraries for enzymes.
Fig. 1. The sreening workflow of Receptor.AI
This approach involves comprehensive molecular simulations of the catalytic and allosteric binding pockets and ensemble virtual screening that accounts for their conformational flexibility. In the case of designing modulators, the structural adjustments caused by reaction intermediates are considered to improve activity and selectivity.
Our library distinguishes itself through several key aspects:
partner
Reaxense
upacc
O95866
UPID:
G6B_HUMAN
Alternative names:
Protein G6b
Alternative UPACC:
O95866; A2BEZ1; A2BEZ2; A2BEZ3; A2BEZ4; A2BEZ5; B0UXC4; B0UXC7; B0UXC8; B0V024; B0V026; Q14CK2; Q96A86; Q96A87; Q96A88; Q96A89; Q96A90; Q96A91
Background:
Megakaryocyte and platelet inhibitory receptor G6b, also known as Protein G6b, plays a pivotal role in hematopoietic lineage differentiation, megakaryocyte function, and platelet production. It inhibits platelet aggregation and activation through its unique structure, featuring a transmembrane region and two immunoreceptor tyrosine-based inhibitor motifs (ITIMs). This protein operates in a calcium-independent manner, regulating megakaryocyte function and platelet production by inhibiting CLEC1B and GP6:FcRgamma signaling pathways.
Therapeutic significance:
Given its critical role in regulating platelet production and function, Megakaryocyte and platelet inhibitory receptor G6b is directly linked to thrombocytopenia, anemia, and myelofibrosis. Understanding the role of this protein could open doors to potential therapeutic strategies for these conditions, offering hope for patients suffering from these debilitating diseases.