Explore the Potential with AI-Driven Innovation
This comprehensive focused library is produced on demand with state-of-the-art virtual screening and parameter assessment technology driven by Receptor.AI drug discovery platform. This approach outperforms traditional methods and provides higher-quality compounds with superior activity, selectivity and safety.
Our selection of compounds is from a large virtual library of over 60 billion molecules. The production and distribution of these compounds are managed by our partner Reaxense.
The library includes a list of the most promising modulators annotated with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Also, each compound is presented with its optimal docking poses, affinity scores, and activity scores, providing a comprehensive overview.
Our top-notch dedicated system is used to design specialised libraries.
Fig. 1. The sreening workflow of Receptor.AI
Our strategy employs molecular simulations to explore an extensive range of proteins, capturing their dynamics both individually and within complexes with other proteins. Through ensemble virtual screening, we address proteins' conformational mobility, uncovering key binding sites at both functional regions and remote allosteric locations. This comprehensive investigation ensures a thorough assessment of all potential mechanisms of action, with the goal of discovering innovative therapeutic targets and lead molecules across across diverse biological functions.
Several key aspects differentiate our library:
partner
Reaxense
upacc
O95995
UPID:
DRC4_HUMAN
Alternative names:
Growth arrest-specific protein 11; Growth arrest-specific protein 8
Alternative UPACC:
O95995; B2RCT1; B7Z4U1; G3V1L5; Q2M234
Background:
Dynein regulatory complex subunit 4, also known as Growth arrest-specific protein 11, plays a pivotal role in ciliary and flagellar motility. It is a component of the nexin-dynein regulatory complex (N-DRC), crucial for maintaining the alignment and integrity of the distal axoneme. This protein is essential for proper functioning of motile cilia, coordinating their movement, and is involved in hedgehog signaling through regulation of smoothened (SMO) activity.
Therapeutic significance:
Given its critical role in motile cilia functioning and hedgehog signaling, Dynein regulatory complex subunit 4 is linked to Ciliary dyskinesia, primary, 33, a disorder characterized by respiratory infections and chronic inflammation due to ciliary defects. Understanding the role of this protein could open doors to potential therapeutic strategies for treating ciliary dyskinesia.