Explore the Potential with AI-Driven Innovation
This comprehensive focused library is produced on demand with state-of-the-art virtual screening and parameter assessment technology driven by Receptor.AI drug discovery platform. This approach outperforms traditional methods and provides higher-quality compounds with superior activity, selectivity and safety.
Our selection of compounds is from a large virtual library of over 60 billion molecules. The production and distribution of these compounds are managed by our partner Reaxense.
The library includes a list of the most effective modulators, each annotated with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Furthermore, each compound is shown with its optimal docking poses, affinity scores, and activity scores, offering a detailed summary.
We use our state-of-the-art dedicated workflow for designing focused libraries for enzymes.
Fig. 1. The sreening workflow of Receptor.AI
It includes comprehensive molecular simulations of the catalytic and allosteric binding pockets and the ensemble virtual screening accounting for their conformational mobility. In the case of designing modulators, the structural changes induced by reaction intermediates are taken into account to leverage activity and selectivity.
Our library distinguishes itself through several key aspects:
partner
Reaxense
upacc
P00387
UPID:
NB5R3_HUMAN
Alternative names:
Diaphorase-1
Alternative UPACC:
P00387; B1AHF2; B7Z7L3; O75675; Q8TDL8; Q8WTS8; Q9UEN4; Q9UEN5; Q9UL55; Q9UL56
Background:
NADH-cytochrome b5 reductase 3, also known as Diaphorase-1, plays a crucial role in cellular processes by catalyzing the reduction of cytochrome b5 using NADH as the electron donor. This enzyme is pivotal in maintaining the balance of electron transfer reactions within cells.
Therapeutic significance:
Methemoglobinemia CYB5R3-related, a condition marked by reduced oxygen transport in the blood due to excessive methemoglobin, is directly linked to mutations in the gene encoding NADH-cytochrome b5 reductase 3. Understanding the enzyme's function could lead to targeted therapies for this disease, enhancing patient outcomes.