Explore the Potential with AI-Driven Innovation
The focused library is created on demand with the latest virtual screening and parameter assessment technology, supported by the Receptor.AI drug discovery platform. This method is more effective than traditional methods and results in higher-quality compounds with better activity, selectivity, and safety.
From a virtual chemical space containing more than 60 billion molecules, we precisely choose certain compounds. Our collaborator, Reaxense, aids in their synthesis and provision.
In the library, a selection of top modulators is provided, each marked with 38 ADME-Tox and 32 parameters related to physicochemical properties and drug-likeness. Also, every compound comes with its best docking poses, affinity scores, and activity scores, providing a comprehensive overview.
We employ our advanced, specialised process to create targeted libraries for enzymes.
Fig. 1. The sreening workflow of Receptor.AI
It includes in-depth molecular simulations of both the catalytic and allosteric binding pockets, with ensemble virtual screening focusing on their conformational flexibility. For modulators, the process includes considering the structural shifts due to reaction intermediates to boost activity and selectivity.
Our library stands out due to several important features:
partner
Reaxense
upacc
P01127
UPID:
PDGFB_HUMAN
Alternative names:
PDGF-2; Platelet-derived growth factor B chain; Platelet-derived growth factor beta polypeptide; Proto-oncogene c-Sis
Alternative UPACC:
P01127; G3XAG8; P78431; Q15354; Q6FHE7; Q9UF23
Background:
Platelet-derived growth factor subunit B (PDGF-B), also known as PDGF-2, plays a pivotal role in embryonic development, cell proliferation, migration, survival, and chemotaxis. It is a potent mitogen for mesenchymal cells and is crucial for the normal development of various tissues, including the central nervous system, skin, lung, heart, and placenta. PDGF-B's role in blood vessel development and wound healing underscores its importance in physiological processes.
Therapeutic significance:
PDGF-B's involvement in Basal ganglia calcification, idiopathic, 5, a condition characterized by brain calcifications and a spectrum of neuropsychiatric symptoms, highlights its potential as a therapeutic target. Understanding the role of PDGF-B could open doors to potential therapeutic strategies for this and related disorders.