Explore the Potential with AI-Driven Innovation
Our detailed focused library is generated on demand with advanced virtual screening and parameter assessment technology powered by the Receptor.AI drug discovery platform. This method surpasses traditional approaches, delivering compounds of better quality with enhanced activity, selectivity, and safety.
From a virtual chemical space containing more than 60 billion molecules, we precisely choose certain compounds. Our collaborator, Reaxense, aids in their synthesis and provision.
Contained in the library are leading modulators, each labelled with 38 ADME-Tox and 32 physicochemical and drug-likeness qualities. In addition, each compound is illustrated with its optimal docking poses, affinity scores, and activity scores, giving a complete picture.
We utilise our cutting-edge, exclusive workflow to develop focused libraries.
Fig. 1. The sreening workflow of Receptor.AI
Utilising molecular simulations, our approach thoroughly examines a wide array of proteins, tracking their conformational changes individually and within complexes. Ensemble virtual screening enables us to address conformational flexibility, revealing essential binding sites at functional regions and allosteric locations. Our rigorous analysis guarantees that no potential mechanism of action is overlooked, aiming to uncover new therapeutic targets and lead compounds across diverse biological functions.
Key features that set our library apart include:
partner
Reaxense
upacc
P01225
UPID:
FSHB_HUMAN
Alternative names:
Follicle-stimulating hormone beta subunit; Follitropin beta chain
Alternative UPACC:
P01225; A2TF08; A5JVV3; Q14D61
Background:
Follitropin subunit beta, also known as the follicle-stimulating hormone beta subunit, plays a crucial role in reproductive health. It forms follitropin with the alpha chain CGA, targeting FSHR on reproductive organs to facilitate follicle development and spermatogenesis.
Therapeutic significance:
Linked to Hypogonadotropic hypogonadism 24, a disorder affecting sexual maturation and fertility, understanding Follitropin subunit beta's function could unveil new therapeutic avenues for treating infertility and related conditions.