Explore the Potential with AI-Driven Innovation
This extensive focused library is tailor-made using the latest virtual screening and parameter assessment technology, operated by the Receptor.AI drug discovery platform. This technique is more effective than traditional methods, offering compounds with improved activity, selectivity, and safety.
We carefully select specific compounds from a vast collection of over 60 billion molecules in virtual chemical space. Our partner Reaxense helps in synthesizing and delivering these compounds.
In the library, a selection of top modulators is provided, each marked with 38 ADME-Tox and 32 parameters related to physicochemical properties and drug-likeness. Also, every compound comes with its best docking poses, affinity scores, and activity scores, providing a comprehensive overview.
We utilise our cutting-edge, exclusive workflow to develop focused libraries.
Fig. 1. The sreening workflow of Receptor.AI
By deploying molecular simulations, our approach comprehensively covers a broad array of proteins, tracking their flexibility and dynamics individually and within complexes. Ensemble virtual screening is utilised to take into account conformational dynamics, identifying pivotal binding sites located within functional regions and at allosteric locations. This thorough exploration ensures that every conceivable mechanism of action is considered, aiming to identify new therapeutic targets and advance lead compounds throughout a vast spectrum of biological functions.
Our library is unique due to several crucial aspects:
partner
Reaxense
upacc
P01236
UPID:
PRL_HUMAN
Alternative names:
-
Alternative UPACC:
P01236; Q15199; Q92996
Background:
Prolactin, encoded by the gene with the accession number P01236, is a pivotal hormone primarily known for its role in lactation. It stimulates the mammary glands to produce milk, playing a crucial role in maternal behavior and neonatal survival. Beyond its well-documented function in lactation, prolactin participates in a variety of biological processes, including but not limited to immune response modulation and osmoregulation.
Therapeutic significance:
Understanding the role of Prolactin could open doors to potential therapeutic strategies. Its multifaceted role in biological systems makes it an intriguing subject for scientific inquiry, potentially leading to breakthroughs in treating disorders related to lactation, immune system dysregulation, and water balance.