Explore the Potential with AI-Driven Innovation
Our detailed focused library is generated on demand with advanced virtual screening and parameter assessment technology powered by the Receptor.AI drug discovery platform. This method surpasses traditional approaches, delivering compounds of better quality with enhanced activity, selectivity, and safety.
We pick out particular compounds from an extensive virtual database of more than 60 billion molecules. The preparation and shipment of these compounds are facilitated by our associate Reaxense.
The library includes a list of the most effective modulators, each annotated with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Furthermore, each compound is shown with its optimal docking poses, affinity scores, and activity scores, offering a detailed summary.
Our high-tech, dedicated method is applied to construct targeted libraries for enzymes.
Fig. 1. The sreening workflow of Receptor.AI
It includes in-depth molecular simulations of both the catalytic and allosteric binding pockets, with ensemble virtual screening focusing on their conformational flexibility. For modulators, the process includes considering the structural shifts due to reaction intermediates to boost activity and selectivity.
Our library distinguishes itself through several key aspects:
partner
Reaxense
upacc
P01857
UPID:
IGHG1_HUMAN
Alternative names:
Ig gamma-1 chain C region; Ig gamma-1 chain C region EU; Ig gamma-1 chain C region KOL; Ig gamma-1 chain C region NIE
Alternative UPACC:
P01857; A0A0A0MS08
Background:
The Immunoglobulin heavy constant gamma 1 (IGHG1) protein, known by alternative names such as Ig gamma-1 chain C region, plays a pivotal role in the immune response. It is a crucial component of immunoglobulins or antibodies, produced by B lymphocytes. These antibodies have a unique ability to bind specific antigens, triggering immune reactions that target and eliminate the antigens. The variable domains of these antibodies undergo a sophisticated process of V-(D)-J rearrangement, allowing for a highly specific immune response.
Therapeutic significance:
IGHG1's involvement in multiple myeloma, a malignant tumor of plasma cells, underscores its therapeutic significance. The disease is characterized by skeletal system involvement, hyperglobulinemia, and renal failure, among other symptoms. Genetic aberrations affecting IGHG1, such as chromosomal translocations, are pivotal in the disease's pathogenesis. Understanding the role of IGHG1 could open doors to potential therapeutic strategies targeting these genetic anomalies.