Explore the Potential with AI-Driven Innovation
The specialised, focused library is developed on demand with the most recent virtual screening and parameter assessment technology, guided by the Receptor.AI drug discovery platform. This approach exceeds the capabilities of traditional methods and offers compounds with higher activity, selectivity, and safety.
We carefully select specific compounds from a vast collection of over 60 billion molecules in virtual chemical space. Our partner Reaxense helps in synthesizing and delivering these compounds.
Contained in the library are leading modulators, each labelled with 38 ADME-Tox and 32 physicochemical and drug-likeness qualities. In addition, each compound is illustrated with its optimal docking poses, affinity scores, and activity scores, giving a complete picture.
We employ our advanced, specialised process to create targeted libraries for enzymes.
Fig. 1. The sreening workflow of Receptor.AI
This approach involves comprehensive molecular simulations of the catalytic and allosteric binding pockets and ensemble virtual screening that accounts for their conformational flexibility. In the case of designing modulators, the structural adjustments caused by reaction intermediates are considered to improve activity and selectivity.
Key features that set our library apart include:
partner
Reaxense
upacc
P02775
UPID:
CXCL7_HUMAN
Alternative names:
C-X-C motif chemokine 7; Leukocyte-derived growth factor; Macrophage-derived growth factor; Small-inducible cytokine B7
Alternative UPACC:
P02775; B2R5F3; Q6IBJ8
Background:
Platelet basic protein, also known as C-X-C motif chemokine 7, plays a pivotal role in various biological processes. It is involved in DNA synthesis, mitosis, glycolysis, and the secretion of several substances including prostaglandin E2 and plasminogen activator. Its ability to act as a chemoattractant and activator for neutrophils through its forms such as NAP-2 highlights its significance in immune responses. Additionally, its derivatives, TC-1 and TC-2, exhibit antibacterial properties, showcasing its multifunctionality in host defense mechanisms.
Therapeutic significance:
Understanding the role of Platelet basic protein could open doors to potential therapeutic strategies. Its involvement in critical cellular processes and immune responses positions it as a key target for drug discovery efforts aimed at treating inflammatory conditions and infections.