Explore the Potential with AI-Driven Innovation
The focused library is created on demand with the latest virtual screening and parameter assessment technology, supported by the Receptor.AI drug discovery platform. This method is more effective than traditional methods and results in higher-quality compounds with better activity, selectivity, and safety.
We carefully select specific compounds from a vast collection of over 60 billion molecules in virtual chemical space. Our partner Reaxense helps in synthesizing and delivering these compounds.
The library includes a list of the most effective modulators, each annotated with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Furthermore, each compound is shown with its optimal docking poses, affinity scores, and activity scores, offering a detailed summary.
Our high-tech, dedicated method is applied to construct targeted libraries for enzymes.
Fig. 1. The sreening workflow of Receptor.AI
The method includes detailed molecular simulations of the catalytic and allosteric binding pockets, along with ensemble virtual screening that considers their conformational flexibility. In the design of modulators, structural changes induced by reaction intermediates are taken into account to enhance activity and selectivity.
Our library stands out due to several important features:
partner
Reaxense
upacc
P03950
UPID:
ANGI_HUMAN
Alternative names:
Ribonuclease 5
Alternative UPACC:
P03950; Q05CV1; Q53X86; Q6P5T2; Q8WXE7
Background:
Angiogenin, also known as Ribonuclease 5, plays a pivotal role in cellular stress response by cleaving tRNA to produce stress-induced fragments. These fragments inhibit protein synthesis and facilitate the assembly of stress granules, crucial for cell survival under adverse conditions. Additionally, angiogenin's involvement in vascularization and ribosomal RNA synthesis underscores its significance in both normal and pathological tissue development.
Therapeutic significance:
Given its role in the pathogenesis of Amyotrophic Lateral Sclerosis 9 (ALS9), where it's associated with genetic variants affecting its gene, angiogenin represents a promising target for therapeutic intervention. Understanding the multifaceted functions of angiogenin could pave the way for novel treatments for ALS9, a devastating neurodegenerative disorder.