Explore the Potential with AI-Driven Innovation
This comprehensive focused library is produced on demand with state-of-the-art virtual screening and parameter assessment technology driven by Receptor.AI drug discovery platform. This approach outperforms traditional methods and provides higher-quality compounds with superior activity, selectivity and safety.
We carefully select specific compounds from a vast collection of over 60 billion molecules in virtual chemical space. Our partner Reaxense helps in synthesizing and delivering these compounds.
In the library, a selection of top modulators is provided, each marked with 38 ADME-Tox and 32 parameters related to physicochemical properties and drug-likeness. Also, every compound comes with its best docking poses, affinity scores, and activity scores, providing a comprehensive overview.
Our high-tech, dedicated method is applied to construct targeted libraries.
Fig. 1. The sreening workflow of Receptor.AI
Our methodology employs molecular simulations to explore a wide array of proteins, capturing their dynamic states both individually and within complexes. Through ensemble virtual screening, we address conformational mobility, uncovering binding sites within functional regions and remote allosteric locations. This thorough exploration ensures no potential mechanism of action is overlooked, aiming to discover novel therapeutic targets and lead compounds across an extensive spectrum of biological functions.
Our library distinguishes itself through several key aspects:
partner
Reaxense
upacc
P04141
UPID:
CSF2_HUMAN
Alternative names:
Colony-stimulating factor; Molgramostin; Sargramostim
Alternative UPACC:
P04141; Q14CE8; Q2VPI8; Q8NFI6
Background:
Granulocyte-macrophage colony-stimulating factor (GM-CSF), also known as Colony-stimulating factor, Molgramostin, and Sargramostim, is a pivotal cytokine. It plays a crucial role in the growth and differentiation of hematopoietic precursor cells into various lineages, including granulocytes, macrophages, eosinophils, and erythrocytes.
Therapeutic significance:
Understanding the role of Granulocyte-macrophage colony-stimulating factor could open doors to potential therapeutic strategies. Its ability to influence the hematopoietic system suggests its utility in treating conditions related to blood and immune cells.