Explore the Potential with AI-Driven Innovation
The focused library is created on demand with the latest virtual screening and parameter assessment technology, supported by the Receptor.AI drug discovery platform. This method is more effective than traditional methods and results in higher-quality compounds with better activity, selectivity, and safety.
Our selection of compounds is from a large virtual library of over 60 billion molecules. The production and distribution of these compounds are managed by our partner Reaxense.
The library features a range of promising modulators, each detailed with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Plus, each compound is presented with its ideal docking poses, affinity scores, and activity scores, ensuring a thorough insight.
We utilise our cutting-edge, exclusive workflow to develop focused libraries.
Fig. 1. The sreening workflow of Receptor.AI
Our methodology employs molecular simulations to explore a wide array of proteins, capturing their dynamic states both individually and within complexes. Through ensemble virtual screening, we address conformational mobility, uncovering binding sites within functional regions and remote allosteric locations. This thorough exploration ensures no potential mechanism of action is overlooked, aiming to discover novel therapeutic targets and lead compounds across an extensive spectrum of biological functions.
Our library stands out due to several important features:
partner
Reaxense
upacc
P05141
UPID:
ADT2_HUMAN
Alternative names:
ADP,ATP carrier protein 2; ADP,ATP carrier protein, fibroblast isoform; Adenine nucleotide translocator 2; Solute carrier family 25 member 5
Alternative UPACC:
P05141; B2RCV1; O43350
Background:
ADP/ATP translocase 2, also known as Solute carrier family 25 member 5, plays a crucial role in cellular energy metabolism. It facilitates the exchange of ADP and ATP across the mitochondrial membrane, balancing ATP production and thermogenesis. This protein is pivotal in mitochondrial uncoupling and the mitochondrial permeability transition pore (mPTP) activity, influencing cell death and thermoregulation.
Therapeutic significance:
Understanding the role of ADP/ATP translocase 2 could open doors to potential therapeutic strategies. Its involvement in mitochondrial function and energy metabolism makes it a target for addressing metabolic disorders and diseases related to mitochondrial dysfunction.