Focused On-demand Library for Eukaryotic translation initiation factor 2 subunit 1

Focused On-demand Libraries - Reaxense Collaboration

Explore the Potential with AI-Driven Innovation

The specialised, focused library is developed on demand with the most recent virtual screening and parameter assessment technology, guided by the Receptor.AI drug discovery platform. This approach exceeds the capabilities of traditional methods and offers compounds with higher activity, selectivity, and safety.

Our selection of compounds is from a large virtual library of over 60 billion molecules. The production and distribution of these compounds are managed by our partner Reaxense.

In the library, a selection of top modulators is provided, each marked with 38 ADME-Tox and 32 parameters related to physicochemical properties and drug-likeness. Also, every compound comes with its best docking poses, affinity scores, and activity scores, providing a comprehensive overview.

Our high-tech, dedicated method is applied to construct targeted libraries.

Fig. 1. The sreening workflow of Receptor.AI

Our strategy employs molecular simulations to explore an extensive range of proteins, capturing their dynamics both individually and within complexes with other proteins. Through ensemble virtual screening, we address proteins' conformational mobility, uncovering key binding sites at both functional regions and remote allosteric locations. This comprehensive investigation ensures a thorough assessment of all potential mechanisms of action, with the goal of discovering innovative therapeutic targets and lead molecules across across diverse biological functions.

Key features that set our library apart include:

The Receptor.AI platform integrates extensive information about the target protein, such as historical experiments, academic research, known ligands, and structural insights, thereby increasing the likelihood of identifying highly relevant compounds.
The platform’s sophisticated molecular simulations are designed to discover potential binding sites, ensuring that our focused library is optimal for the discovery of allosteric inhibitors and binders for cryptic pockets.
With over 50 customisable AI models, verified through extensive testing in commercial drug discovery and research, Receptor.AI is efficient, reliable, and precise. These models are essential in the production of our focused libraries.
Receptor.AI not only produces focused libraries but also provides full services and solutions at every stage of preclinical drug discovery, with a success-based pricing structure that aligns our interests with the success of your project.

partner

Reaxense

upacc

P05198

UPID:

IF2A_HUMAN

Alternative names:

Eukaryotic translation initiation factor 2 subunit alpha

Alternative UPACC:

P05198

Background:

Eukaryotic translation initiation factor 2 subunit 1 (EIF2S1), also known as eIF2-alpha, plays a pivotal role in protein synthesis. It forms a ternary complex with GTP and initiator tRNA, essential for the early steps of translation. This complex's binding to a 40S ribosomal subunit and subsequent mRNA binding initiates the formation of a 43S pre-initiation complex. The process culminates in the 80S initiation complex, crucial for protein synthesis. EIF2S1 is also integral to the integrated stress response, modulating protein synthesis in response to cellular stress by regulating ATF4 and QRICH1 expression.

Therapeutic significance:

Understanding the role of Eukaryotic translation initiation factor 2 subunit 1 could open doors to potential therapeutic strategies.