Explore the Potential with AI-Driven Innovation
Our detailed focused library is generated on demand with advanced virtual screening and parameter assessment technology powered by the Receptor.AI drug discovery platform. This method surpasses traditional approaches, delivering compounds of better quality with enhanced activity, selectivity, and safety.
Our selection of compounds is from a large virtual library of over 60 billion molecules. The production and distribution of these compounds are managed by our partner Reaxense.
The library includes a list of the most promising modulators annotated with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Also, each compound is presented with its optimal docking poses, affinity scores, and activity scores, providing a comprehensive overview.
Our high-tech, dedicated method is applied to construct targeted libraries for enzymes.
Fig. 1. The sreening workflow of Receptor.AI
The method includes detailed molecular simulations of the catalytic and allosteric binding pockets, along with ensemble virtual screening that considers their conformational flexibility. In the design of modulators, structural changes induced by reaction intermediates are taken into account to enhance activity and selectivity.
Key features that set our library apart include:
partner
Reaxense
upacc
P07205
UPID:
PGK2_HUMAN
Alternative names:
Phosphoglycerate kinase, testis specific
Alternative UPACC:
P07205; B2R6Y8; Q9H107
Background:
Phosphoglycerate kinase 2, also known as testis-specific phosphoglycerate kinase, plays a crucial role in sperm motility and male fertility. Despite its non-essential role in spermatogenesis completion, its unique function underscores its importance in reproductive biology.
Therapeutic significance:
Understanding the role of Phosphoglycerate kinase 2 could open doors to potential therapeutic strategies. Its pivotal function in male fertility highlights its potential as a target for addressing reproductive health issues.