Explore the Potential with AI-Driven Innovation
The specialised, focused library is developed on demand with the most recent virtual screening and parameter assessment technology, guided by the Receptor.AI drug discovery platform. This approach exceeds the capabilities of traditional methods and offers compounds with higher activity, selectivity, and safety.
The compounds are cherry-picked from the vast virtual chemical space of over 60B molecules. The synthesis and delivery of compounds is facilitated by our partner Reaxense.
In the library, a selection of top modulators is provided, each marked with 38 ADME-Tox and 32 parameters related to physicochemical properties and drug-likeness. Also, every compound comes with its best docking poses, affinity scores, and activity scores, providing a comprehensive overview.
Our top-notch dedicated system is used to design specialised libraries.
Fig. 1. The sreening workflow of Receptor.AI
Our methodology employs molecular simulations to explore a wide array of proteins, capturing their dynamic states both individually and within complexes. Through ensemble virtual screening, we address conformational mobility, uncovering binding sites within functional regions and remote allosteric locations. This thorough exploration ensures no potential mechanism of action is overlooked, aiming to discover novel therapeutic targets and lead compounds across an extensive spectrum of biological functions.
Key features that set our library apart include:
partner
Reaxense
upacc
P07942
UPID:
LAMB1_HUMAN
Alternative names:
Laminin B1 chain; Laminin-1 subunit beta; Laminin-10 subunit beta; Laminin-12 subunit beta; Laminin-2 subunit beta; Laminin-6 subunit beta; Laminin-8 subunit beta
Alternative UPACC:
P07942; Q14D91
Background:
Laminin subunit beta-1, known by alternative names such as Laminin B1 chain and Laminin-2 subunit beta, plays a pivotal role in the embryonic development by mediating cell attachment, migration, and organization into tissues. It is crucial for the cerebral cortex's laminar architecture and the integrity of the basement membrane, serving as an anchor for radial glial cells and a barrier to migrating neurons.
Therapeutic significance:
Laminin subunit beta-1's involvement in Lissencephaly 5, a severe brain malformation, underscores its therapeutic significance. Understanding its role could lead to novel strategies for treating this and potentially other neurodevelopmental disorders.