Explore the Potential with AI-Driven Innovation
The specialised, focused library is developed on demand with the most recent virtual screening and parameter assessment technology, guided by the Receptor.AI drug discovery platform. This approach exceeds the capabilities of traditional methods and offers compounds with higher activity, selectivity, and safety.
We carefully select specific compounds from a vast collection of over 60 billion molecules in virtual chemical space. Our partner Reaxense helps in synthesizing and delivering these compounds.
Contained in the library are leading modulators, each labelled with 38 ADME-Tox and 32 physicochemical and drug-likeness qualities. In addition, each compound is illustrated with its optimal docking poses, affinity scores, and activity scores, giving a complete picture.
Our top-notch dedicated system is used to design specialised libraries for receptors.
Fig. 1. The sreening workflow of Receptor.AI
This process includes extensive molecular simulations of the receptor in its native membrane environment, along with ensemble virtual screening that accounts for its conformational mobility. In the case of dimeric or oligomeric receptors, the entire functional complex is modelled, identifying potential binding pockets on and between the subunits to encompass all possible mechanisms of action.
Our library stands out due to several important features:
partner
Reaxense
upacc
P08172
UPID:
ACM2_HUMAN
Alternative names:
-
Alternative UPACC:
P08172; Q4VBK6; Q9P1X9
Background:
The Muscarinic acetylcholine receptor M2 plays a pivotal role in mediating cellular responses through G proteins. Its primary function includes inhibition of adenylate cyclase, modulation of potassium channels, and promoting phospholipase C activity. This leads to the release of calcium ions into the cytosol, integral for various physiological processes.
Therapeutic significance:
Given its involvement in major depressive disorder, understanding the role of Muscarinic acetylcholine receptor M2 could open doors to potential therapeutic strategies. Disease susceptibility is linked to gene variants, highlighting its significance in psychiatric disorder management.