Explore the Potential with AI-Driven Innovation
The specialised, focused library is developed on demand with the most recent virtual screening and parameter assessment technology, guided by the Receptor.AI drug discovery platform. This approach exceeds the capabilities of traditional methods and offers compounds with higher activity, selectivity, and safety.
The compounds are cherry-picked from the vast virtual chemical space of over 60B molecules. The synthesis and delivery of compounds is facilitated by our partner Reaxense.
In the library, a selection of top modulators is provided, each marked with 38 ADME-Tox and 32 parameters related to physicochemical properties and drug-likeness. Also, every compound comes with its best docking poses, affinity scores, and activity scores, providing a comprehensive overview.
We employ our advanced, specialised process to create targeted libraries.
Fig. 1. The sreening workflow of Receptor.AI
Our strategy employs molecular simulations to explore an extensive range of proteins, capturing their dynamics both individually and within complexes with other proteins. Through ensemble virtual screening, we address proteins' conformational mobility, uncovering key binding sites at both functional regions and remote allosteric locations. This comprehensive investigation ensures a thorough assessment of all potential mechanisms of action, with the goal of discovering innovative therapeutic targets and lead molecules across across diverse biological functions.
Our library is unique due to several crucial aspects:
partner
Reaxense
upacc
P08247
UPID:
SYPH_HUMAN
Alternative names:
Major synaptic vesicle protein p38
Alternative UPACC:
P08247; B2R7L6; B7Z359; Q6P2F7
Background:
Synaptophysin, also known as Major synaptic vesicle protein p38, plays a crucial role in the nervous system. It is involved in organizing membrane components and targeting vesicles to the plasma membrane, essential for synaptic plasticity. This protein's functions are pivotal for both short-term and long-term synaptic adjustments, which are fundamental for learning and memory.
Therapeutic significance:
Synaptophysin is linked to Intellectual developmental disorder, X-linked 96, a condition marked by below-average intellectual functioning and adaptive behavior impairments. Understanding the role of Synaptophysin could open doors to potential therapeutic strategies for this disorder, highlighting its importance in neurodevelopmental disease research.