Explore the Potential with AI-Driven Innovation
Our detailed focused library is generated on demand with advanced virtual screening and parameter assessment technology powered by the Receptor.AI drug discovery platform. This method surpasses traditional approaches, delivering compounds of better quality with enhanced activity, selectivity, and safety.
The compounds are cherry-picked from the vast virtual chemical space of over 60B molecules. The synthesis and delivery of compounds is facilitated by our partner Reaxense.
The library includes a list of the most promising modulators annotated with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Also, each compound is presented with its optimal docking poses, affinity scores, and activity scores, providing a comprehensive overview.
Our high-tech, dedicated method is applied to construct targeted libraries for enzymes.
Fig. 1. The sreening workflow of Receptor.AI
It includes in-depth molecular simulations of both the catalytic and allosteric binding pockets, with ensemble virtual screening focusing on their conformational flexibility. For modulators, the process includes considering the structural shifts due to reaction intermediates to boost activity and selectivity.
Our library distinguishes itself through several key aspects:
partner
Reaxense
upacc
P08574
UPID:
CY1_HUMAN
Alternative names:
Complex III subunit 4; Complex III subunit IV; Cytochrome b-c1 complex subunit 4; Ubiquinol-cytochrome-c reductase complex cytochrome c1 subunit
Alternative UPACC:
P08574; Q5U062; Q6FHS7
Background:
Cytochrome c1, heme protein, mitochondrial, known as Complex III subunit 4, plays a pivotal role in the mitochondrial electron transport chain. This protein is integral to the process of oxidative phosphorylation, facilitating the transfer of electrons from ubiquinol to cytochrome c and contributing to the generation of ATP.
Therapeutic significance:
Linked to Mitochondrial complex III deficiency, nuclear type 6, Cytochrome c1's dysfunction underscores its potential as a target for therapeutic intervention. Understanding its role could pave the way for novel treatments for mitochondrial disorders.