Explore the Potential with AI-Driven Innovation
Our detailed focused library is generated on demand with advanced virtual screening and parameter assessment technology powered by the Receptor.AI drug discovery platform. This method surpasses traditional approaches, delivering compounds of better quality with enhanced activity, selectivity, and safety.
We carefully select specific compounds from a vast collection of over 60 billion molecules in virtual chemical space. Our partner Reaxense helps in synthesizing and delivering these compounds.
In the library, a selection of top modulators is provided, each marked with 38 ADME-Tox and 32 parameters related to physicochemical properties and drug-likeness. Also, every compound comes with its best docking poses, affinity scores, and activity scores, providing a comprehensive overview.
We utilise our cutting-edge, exclusive workflow to develop focused libraries.
Fig. 1. The sreening workflow of Receptor.AI
Our methodology employs molecular simulations to explore a wide array of proteins, capturing their dynamic states both individually and within complexes. Through ensemble virtual screening, we address conformational mobility, uncovering binding sites within functional regions and remote allosteric locations. This thorough exploration ensures no potential mechanism of action is overlooked, aiming to discover novel therapeutic targets and lead compounds across an extensive spectrum of biological functions.
Our library stands out due to several important features:
partner
Reaxense
upacc
P09132
UPID:
SRP19_HUMAN
Alternative names:
-
Alternative UPACC:
P09132; B2R4E9; D6RCQ5; Q05D77; Q96FG6
Background:
The Signal recognition particle 19 kDa protein plays a crucial role in the signal recognition particle (SRP) complex, essential for the cotranslational targeting of proteins to the endoplasmic reticulum. It binds directly to 7SL RNA and facilitates the incorporation of SRP54 into the SRP complex, highlighting its pivotal role in protein translocation.
Therapeutic significance:
Understanding the role of Signal recognition particle 19 kDa protein could open doors to potential therapeutic strategies.