Explore the Potential with AI-Driven Innovation
Our detailed focused library is generated on demand with advanced virtual screening and parameter assessment technology powered by the Receptor.AI drug discovery platform. This method surpasses traditional approaches, delivering compounds of better quality with enhanced activity, selectivity, and safety.
We carefully select specific compounds from a vast collection of over 60 billion molecules in virtual chemical space. Our partner Reaxense helps in synthesizing and delivering these compounds.
The library features a range of promising modulators, each detailed with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Plus, each compound is presented with its ideal docking poses, affinity scores, and activity scores, ensuring a thorough insight.
Our top-notch dedicated system is used to design specialised libraries for enzymes.
Fig. 1. The sreening workflow of Receptor.AI
It includes comprehensive molecular simulations of the catalytic and allosteric binding pockets and the ensemble virtual screening accounting for their conformational mobility. In the case of designing modulators, the structural changes induced by reaction intermediates are taken into account to leverage activity and selectivity.
Our library is unique due to several crucial aspects:
partner
Reaxense
upacc
P09488
UPID:
GSTM1_HUMAN
Alternative names:
GST HB subunit 4; GST class-mu 1; GSTM1-1; GSTM1a-1a; GSTM1b-1b; GTH4
Alternative UPACC:
P09488; Q5GHG0; Q6FH88; Q8TC98; Q9UC96
Background:
Glutathione S-transferase Mu 1 (GST Mu 1), known by alternative names such as GST HB subunit 4 and GSTM1-1, plays a crucial role in detoxifying cells. It achieves this by conjugating reduced glutathione to a variety of hydrophobic electrophiles, including prostaglandin A2 and J2. This protein is also involved in the formation of novel hepoxilin regioisomers, showcasing its versatility in cellular processes.
Therapeutic significance:
Understanding the role of Glutathione S-transferase Mu 1 could open doors to potential therapeutic strategies. Its pivotal function in detoxification and metabolism positions it as a key target for drug discovery, aiming to enhance cellular resilience against toxic compounds.