Explore the Potential with AI-Driven Innovation
This comprehensive focused library is produced on demand with state-of-the-art virtual screening and parameter assessment technology driven by Receptor.AI drug discovery platform. This approach outperforms traditional methods and provides higher-quality compounds with superior activity, selectivity and safety.
The compounds are cherry-picked from the vast virtual chemical space of over 60B molecules. The synthesis and delivery of compounds is facilitated by our partner Reaxense.
The library features a range of promising modulators, each detailed with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Plus, each compound is presented with its ideal docking poses, affinity scores, and activity scores, ensuring a thorough insight.
We utilise our cutting-edge, exclusive workflow to develop focused libraries.
Fig. 1. The sreening workflow of Receptor.AI
Our strategy employs molecular simulations to explore an extensive range of proteins, capturing their dynamics both individually and within complexes with other proteins. Through ensemble virtual screening, we address proteins' conformational mobility, uncovering key binding sites at both functional regions and remote allosteric locations. This comprehensive investigation ensures a thorough assessment of all potential mechanisms of action, with the goal of discovering innovative therapeutic targets and lead molecules across across diverse biological functions.
Our library distinguishes itself through several key aspects:
partner
Reaxense
upacc
P09758
UPID:
TACD2_HUMAN
Alternative names:
Cell surface glycoprotein Trop-2; Membrane component chromosome 1 surface marker 1; Pancreatic carcinoma marker protein GA733-1
Alternative UPACC:
P09758; Q15658; Q6FG48; Q7Z7Q4; Q96QD2
Background:
Tumor-associated calcium signal transducer 2 (TACSTD2), also known as Cell surface glycoprotein Trop-2, plays a pivotal role in cellular signaling and growth. Identified as Membrane component chromosome 1 surface marker 1 and Pancreatic carcinoma marker protein GA733-1, TACSTD2's involvement in various cellular processes underscores its biological significance.
Therapeutic significance:
TACSTD2's link to Corneal dystrophy, gelatinous drop-like, a severe corneal amyloidosis leading to blindness, highlights its therapeutic potential. Understanding TACSTD2's function could pave the way for innovative treatments targeting this blinding condition.