Explore the Potential with AI-Driven Innovation
The focused library is created on demand with the latest virtual screening and parameter assessment technology, supported by the Receptor.AI drug discovery platform. This method is more effective than traditional methods and results in higher-quality compounds with better activity, selectivity, and safety.
The compounds are cherry-picked from the vast virtual chemical space of over 60B molecules. The synthesis and delivery of compounds is facilitated by our partner Reaxense.
Contained in the library are leading modulators, each labelled with 38 ADME-Tox and 32 physicochemical and drug-likeness qualities. In addition, each compound is illustrated with its optimal docking poses, affinity scores, and activity scores, giving a complete picture.
Our high-tech, dedicated method is applied to construct targeted libraries.
Fig. 1. The sreening workflow of Receptor.AI
Utilising molecular simulations, our approach thoroughly examines a wide array of proteins, tracking their conformational changes individually and within complexes. Ensemble virtual screening enables us to address conformational flexibility, revealing essential binding sites at functional regions and allosteric locations. Our rigorous analysis guarantees that no potential mechanism of action is overlooked, aiming to uncover new therapeutic targets and lead compounds across diverse biological functions.
Our library distinguishes itself through several key aspects:
partner
Reaxense
upacc
P09914
UPID:
IFIT1_HUMAN
Alternative names:
Interferon-induced 56 kDa protein
Alternative UPACC:
P09914; B3KS50; D3DR31; Q5T7J1; Q96QM5
Background:
The Interferon-induced protein with tetratricopeptide repeats 1, also known as the Interferon-induced 56 kDa protein, plays a pivotal role in the body's defense against viral infections. It binds single-stranded RNA with a 5'-triphosphate group, distinguishing viral RNAs from self RNAs, thereby inhibiting viral mRNA expression. This protein's ability to recognize and bind non-sequence-specific PPP-RNA is crucial for its antiviral activity against viruses like human papilloma and hepatitis C.
Therapeutic significance:
Understanding the role of Interferon-induced protein with tetratricopeptide repeats 1 could open doors to potential therapeutic strategies.