Explore the Potential with AI-Driven Innovation
The specialised, focused library is developed on demand with the most recent virtual screening and parameter assessment technology, guided by the Receptor.AI drug discovery platform. This approach exceeds the capabilities of traditional methods and offers compounds with higher activity, selectivity, and safety.
We pick out particular compounds from an extensive virtual database of more than 60 billion molecules. The preparation and shipment of these compounds are facilitated by our associate Reaxense.
The library includes a list of the most effective modulators, each annotated with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Furthermore, each compound is shown with its optimal docking poses, affinity scores, and activity scores, offering a detailed summary.
We utilise our cutting-edge, exclusive workflow to develop focused libraries.
Fig. 1. The sreening workflow of Receptor.AI
Utilising molecular simulations, our approach thoroughly examines a wide array of proteins, tracking their conformational changes individually and within complexes. Ensemble virtual screening enables us to address conformational flexibility, revealing essential binding sites at functional regions and allosteric locations. Our rigorous analysis guarantees that no potential mechanism of action is overlooked, aiming to uncover new therapeutic targets and lead compounds across diverse biological functions.
Our library distinguishes itself through several key aspects:
partner
Reaxense
upacc
P0C0S8
UPID:
H2A1_HUMAN
Alternative names:
Histone H2A/ptl
Alternative UPACC:
P0C0S8; P02261; Q2M1R2; Q76PA6
Background:
Histone H2A type 1, alternatively known as Histone H2A/ptl, is a core component of the nucleosome. Nucleosomes are critical for DNA wrapping and compaction into chromatin, which influences DNA's accessibility to essential cellular processes like transcription regulation, DNA repair, DNA replication, and chromosomal stability. The regulation of DNA accessibility is mediated through histone modifications, part of the histone code, and nucleosome remodeling.
Therapeutic significance:
Understanding the role of Histone H2A type 1 could open doors to potential therapeutic strategies.