Explore the Potential with AI-Driven Innovation
This comprehensive focused library is produced on demand with state-of-the-art virtual screening and parameter assessment technology driven by Receptor.AI drug discovery platform. This approach outperforms traditional methods and provides higher-quality compounds with superior activity, selectivity and safety.
We pick out particular compounds from an extensive virtual database of more than 60 billion molecules. The preparation and shipment of these compounds are facilitated by our associate Reaxense.
In the library, a selection of top modulators is provided, each marked with 38 ADME-Tox and 32 parameters related to physicochemical properties and drug-likeness. Also, every compound comes with its best docking poses, affinity scores, and activity scores, providing a comprehensive overview.
Our high-tech, dedicated method is applied to construct targeted libraries for enzymes.
Fig. 1. The sreening workflow of Receptor.AI
The method includes detailed molecular simulations of the catalytic and allosteric binding pockets, along with ensemble virtual screening that considers their conformational flexibility. In the design of modulators, structural changes induced by reaction intermediates are taken into account to enhance activity and selectivity.
Our library is unique due to several crucial aspects:
partner
Reaxense
upacc
P0C870
UPID:
JMJD7_HUMAN
Alternative names:
JmjC domain-containing protein 7; Jumonji domain-containing protein 7; L-lysine (3S)-hydroxylase JMJD7
Alternative UPACC:
P0C870; A5D6V5; O95712; Q59GF9; Q8TB10; Q9UKV7
Background:
Bifunctional peptidase and (3S)-lysyl hydroxylase JMJD7, also known as JmjC domain-containing protein 7, plays a crucial role in histone modification and protein biosynthesis. It acts as an endopeptidase, cleaving histones' N-terminal tails, and as a monooxygenase, hydroxylating specific lysine residues on translation factors. This dual functionality underscores its importance in transcription regulation and protein synthesis.
Therapeutic significance:
Understanding the role of Bifunctional peptidase and (3S)-lysyl hydroxylase JMJD7 could open doors to potential therapeutic strategies.