Explore the Potential with AI-Driven Innovation
This extensive focused library is tailor-made using the latest virtual screening and parameter assessment technology, operated by the Receptor.AI drug discovery platform. This technique is more effective than traditional methods, offering compounds with improved activity, selectivity, and safety.
From a virtual chemical space containing more than 60 billion molecules, we precisely choose certain compounds. Our collaborator, Reaxense, aids in their synthesis and provision.
The library includes a list of the most effective modulators, each annotated with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Furthermore, each compound is shown with its optimal docking poses, affinity scores, and activity scores, offering a detailed summary.
We use our state-of-the-art dedicated workflow for designing focused libraries for enzymes.
Fig. 1. The sreening workflow of Receptor.AI
This approach involves comprehensive molecular simulations of the catalytic and allosteric binding pockets and ensemble virtual screening that accounts for their conformational flexibility. In the case of designing modulators, the structural adjustments caused by reaction intermediates are considered to improve activity and selectivity.
Our library stands out due to several important features:
partner
Reaxense
upacc
P0DPD7
UPID:
EFMT4_HUMAN
Alternative names:
-
Alternative UPACC:
P0DPD7; A5PLK8; O60344; Q6NTG7; Q6UW36; Q8NFD7; Q96NX3; Q96NX4; Q9BRZ8
Background:
EEF1A lysine methyltransferase 4, encoded by the gene with accession number P0DPD7, plays a pivotal role in protein synthesis. It specifically targets the eukaryotic translation elongation factor 1 alpha, catalyzing up to three methylations on Lys-36. This post-translational modification is crucial for the accurate and efficient production of proteins, highlighting the enzyme's essential role in cellular machinery.
Therapeutic significance:
Understanding the role of EEF1A lysine methyltransferase 4 could open doors to potential therapeutic strategies. Its precise function in protein synthesis regulation suggests that modulating its activity could influence cellular protein levels, offering a novel approach to treating diseases where protein synthesis is dysregulated.