Explore the Potential with AI-Driven Innovation
This extensive focused library is tailor-made using the latest virtual screening and parameter assessment technology, operated by the Receptor.AI drug discovery platform. This technique is more effective than traditional methods, offering compounds with improved activity, selectivity, and safety.
From a virtual chemical space containing more than 60 billion molecules, we precisely choose certain compounds. Our collaborator, Reaxense, aids in their synthesis and provision.
The library features a range of promising modulators, each detailed with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Plus, each compound is presented with its ideal docking poses, affinity scores, and activity scores, ensuring a thorough insight.
Our top-notch dedicated system is used to design specialised libraries for enzymes.
Fig. 1. The sreening workflow of Receptor.AI
The procedure entails thorough molecular simulations of the catalytic and allosteric binding pockets, accompanied by ensemble virtual screening that factors in their conformational flexibility. When developing modulators, the structural modifications brought about by reaction intermediates are factored in to optimize activity and selectivity.
Our library is unique due to several crucial aspects:
partner
Reaxense
upacc
P0DPH7
UPID:
TBA3C_HUMAN
Alternative names:
Alpha-tubulin 2; Alpha-tubulin 3C; Tubulin alpha-2 chain
Alternative UPACC:
P0DPH7; A6NJQ0; Q13748; Q5W099; Q6PEY3; Q96F18
Background:
Tubulin alpha-3C chain, also known as Alpha-tubulin 2, Alpha-tubulin 3C, and Tubulin alpha-2 chain, plays a pivotal role in cell structure and function. It is a major component of microtubules, cylindrical structures essential for cell shape, intracellular transport, and cell division. Microtubules are dynamic entities that grow by adding GTP-tubulin dimers, with alpha-tubulin's GTPase activity crucial for this process.
Therapeutic significance:
Understanding the role of Tubulin alpha-3C chain could open doors to potential therapeutic strategies. Its fundamental involvement in cell division and transport makes it a potential target for cancer therapy, where controlling cell proliferation is crucial.