Explore the Potential with AI-Driven Innovation
Our detailed focused library is generated on demand with advanced virtual screening and parameter assessment technology powered by the Receptor.AI drug discovery platform. This method surpasses traditional approaches, delivering compounds of better quality with enhanced activity, selectivity, and safety.
From a virtual chemical space containing more than 60 billion molecules, we precisely choose certain compounds. Our collaborator, Reaxense, aids in their synthesis and provision.
The library features a range of promising modulators, each detailed with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Plus, each compound is presented with its ideal docking poses, affinity scores, and activity scores, ensuring a thorough insight.
We employ our advanced, specialised process to create targeted libraries for enzymes.
Fig. 1. The sreening workflow of Receptor.AI
It includes in-depth molecular simulations of both the catalytic and allosteric binding pockets, with ensemble virtual screening focusing on their conformational flexibility. For modulators, the process includes considering the structural shifts due to reaction intermediates to boost activity and selectivity.
Our library stands out due to several important features:
partner
Reaxense
upacc
P11801
UPID:
KPSH1_HUMAN
Alternative names:
Protein serine kinase H1
Alternative UPACC:
P11801; Q9NY19
Background:
Serine/threonine-protein kinase H1, also known as Protein serine kinase H1, plays a pivotal role in the regulation of pre-mRNA processing and intranuclear trafficking of SR proteins. These proteins are essential for splicing factor compartment (SFC) activities, influencing the post-transcriptional modification of RNA.
Therapeutic significance:
Understanding the role of Serine/threonine-protein kinase H1 could open doors to potential therapeutic strategies. Its involvement in crucial cellular processes highlights its potential as a target for drug discovery, aiming to modulate pre-mRNA processing in disease states.