Explore the Potential with AI-Driven Innovation
This extensive focused library is tailor-made using the latest virtual screening and parameter assessment technology, operated by the Receptor.AI drug discovery platform. This technique is more effective than traditional methods, offering compounds with improved activity, selectivity, and safety.
We carefully select specific compounds from a vast collection of over 60 billion molecules in virtual chemical space. Our partner Reaxense helps in synthesizing and delivering these compounds.
The library includes a list of the most effective modulators, each annotated with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Furthermore, each compound is shown with its optimal docking poses, affinity scores, and activity scores, offering a detailed summary.
We utilise our cutting-edge, exclusive workflow to develop focused libraries for enzymes.
Fig. 1. The sreening workflow of Receptor.AI
The procedure entails thorough molecular simulations of the catalytic and allosteric binding pockets, accompanied by ensemble virtual screening that factors in their conformational flexibility. When developing modulators, the structural modifications brought about by reaction intermediates are factored in to optimize activity and selectivity.
Our library is unique due to several crucial aspects:
partner
Reaxense
upacc
P12034
UPID:
FGF5_HUMAN
Alternative names:
Heparin-binding growth factor 5; Smag-82
Alternative UPACC:
P12034; B2R554; O75846; Q3Y8M3; Q8NF90
Background:
Fibroblast growth factor 5 (FGF5), also known as Heparin-binding growth factor 5 and Smag-82, plays a pivotal role in cell proliferation and differentiation. It is essential for the normal regulation of the hair growth cycle, acting as an inhibitor of hair elongation by facilitating the transition from the growth phase (anagen) to the regression phase (catagen).
Therapeutic significance:
FGF5's involvement in Trichomegaly, characterized by long eyelashes and eyebrow hypertrichosis, underscores its therapeutic potential. Understanding the role of Fibroblast growth factor 5 could open doors to potential therapeutic strategies for hair growth disorders and related conditions.