Explore the Potential with AI-Driven Innovation
The specialised, focused library is developed on demand with the most recent virtual screening and parameter assessment technology, guided by the Receptor.AI drug discovery platform. This approach exceeds the capabilities of traditional methods and offers compounds with higher activity, selectivity, and safety.
From a virtual chemical space containing more than 60 billion molecules, we precisely choose certain compounds. Our collaborator, Reaxense, aids in their synthesis and provision.
The library includes a list of the most effective modulators, each annotated with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Furthermore, each compound is shown with its optimal docking poses, affinity scores, and activity scores, offering a detailed summary.
We employ our advanced, specialised process to create targeted libraries.
Fig. 1. The sreening workflow of Receptor.AI
Our strategy employs molecular simulations to explore an extensive range of proteins, capturing their dynamics both individually and within complexes with other proteins. Through ensemble virtual screening, we address proteins' conformational mobility, uncovering key binding sites at both functional regions and remote allosteric locations. This comprehensive investigation ensures a thorough assessment of all potential mechanisms of action, with the goal of discovering innovative therapeutic targets and lead molecules across across diverse biological functions.
Our library distinguishes itself through several key aspects:
partner
Reaxense
upacc
P12314
UPID:
FCGR1_HUMAN
Alternative names:
Fc-gamma RI; Fc-gamma RIA
Alternative UPACC:
P12314; P12315; Q5QNW7; Q92495; Q92663
Background:
The High affinity immunoglobulin gamma Fc receptor I, also known as Fc-gamma RI and Fc-gamma RIA, plays a pivotal role in the immune system. It serves as a high affinity receptor for the Fc region of immunoglobulins gamma, engaging in both innate and adaptive immune responses. This receptor is crucial for mediating IgG effector functions on monocytes, including the antibody-dependent cellular cytotoxicity (ADCC) of virus-infected cells.
Therapeutic significance:
Understanding the role of High affinity immunoglobulin gamma Fc receptor I could open doors to potential therapeutic strategies. Its involvement in mediating immune responses positions it as a key target for modulating immune functions in various therapeutic contexts.