Explore the Potential with AI-Driven Innovation
The specialised, focused library is developed on demand with the most recent virtual screening and parameter assessment technology, guided by the Receptor.AI drug discovery platform. This approach exceeds the capabilities of traditional methods and offers compounds with higher activity, selectivity, and safety.
From a virtual chemical space containing more than 60 billion molecules, we precisely choose certain compounds. Our collaborator, Reaxense, aids in their synthesis and provision.
The library features a range of promising modulators, each detailed with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Plus, each compound is presented with its ideal docking poses, affinity scores, and activity scores, ensuring a thorough insight.
We utilise our cutting-edge, exclusive workflow to develop focused libraries.
Fig. 1. The sreening workflow of Receptor.AI
Our methodology leverages molecular simulations to examine a vast array of proteins, capturing their dynamics in both isolated forms and in complexes with other proteins. Through ensemble virtual screening, we thoroughly account for the protein's conformational mobility, identifying critical binding sites within functional regions and distant allosteric locations. This detailed exploration ensures that we comprehensively assess every possible mechanism of action, with the objective of identifying novel therapeutic targets and lead compounds that span a wide spectrum of biological functions.
Key features that set our library apart include:
partner
Reaxense
upacc
P13747
UPID:
HLAE_HUMAN
Alternative names:
MHC class I antigen E
Alternative UPACC:
P13747; E2G051; Q30169; Q6DU44; Q9BT83; Q9GIY7; Q9GIY8
Background:
HLA class I histocompatibility antigen, alpha chain E (HLA-E), a non-classical major histocompatibility class Ib molecule, plays a crucial role in immune self-nonself discrimination. It forms a complex with B2M/beta-2-microglobulin to bind self-peptides from classical MHC class Ia molecules, functioning as a ligand for NK cell inhibitory receptors, thus enabling NK cells to tolerate self. HLA-E's interaction with peptides from stress-induced chaperones or viral proteins alters its recognition by NK cells, impacting immune response.
Therapeutic significance:
Understanding the role of HLA-E could open doors to potential therapeutic strategies, especially considering its involvement in immune evasion mechanisms of pathogens like HIV-1, human cytomegalovirus, and SARS-CoV-2. Its ability to modulate NK cell activity offers a promising avenue for enhancing antiviral and antitumor immunity.