Explore the Potential with AI-Driven Innovation
Our detailed focused library is generated on demand with advanced virtual screening and parameter assessment technology powered by the Receptor.AI drug discovery platform. This method surpasses traditional approaches, delivering compounds of better quality with enhanced activity, selectivity, and safety.
Our selection of compounds is from a large virtual library of over 60 billion molecules. The production and distribution of these compounds are managed by our partner Reaxense.
Contained in the library are leading modulators, each labelled with 38 ADME-Tox and 32 physicochemical and drug-likeness qualities. In addition, each compound is illustrated with its optimal docking poses, affinity scores, and activity scores, giving a complete picture.
We employ our advanced, specialised process to create targeted libraries.
Fig. 1. The sreening workflow of Receptor.AI
Our methodology leverages molecular simulations to examine a vast array of proteins, capturing their dynamics in both isolated forms and in complexes with other proteins. Through ensemble virtual screening, we thoroughly account for the protein's conformational mobility, identifying critical binding sites within functional regions and distant allosteric locations. This detailed exploration ensures that we comprehensively assess every possible mechanism of action, with the objective of identifying novel therapeutic targets and lead compounds that span a wide spectrum of biological functions.
Our library is unique due to several crucial aspects:
partner
Reaxense
upacc
P14598
UPID:
NCF1_HUMAN
Alternative names:
47 kDa autosomal chronic granulomatous disease protein; 47 kDa neutrophil oxidase factor; NCF-47K; Neutrophil NADPH oxidase factor 1; Nox organizer 2; Nox-organizing protein 2; SH3 and PX domain-containing protein 1A; p47-phox
Alternative UPACC:
P14598; A6NEH2; A8K7S9; O43842; Q2PP07; Q53FR5; Q9BU90; Q9BXI7; Q9BXI8; Q9UDV9; Q9UMU2
Background:
Neutrophil cytosol factor 1 (NCF1), also known by several alternative names such as p47-phox, plays a pivotal role in the immune system's response to infection. It is a crucial component of the NADPH oxidase complex, which is essential for the production of reactive oxygen species (ROS) by phagocytes. These ROS are vital for the destruction of invading pathogens, highlighting NCF1's role in host defense mechanisms.
Therapeutic significance:
Mutations in NCF1 are linked to Granulomatous disease, chronic, autosomal recessive, 1, characterized by severe infections and chronic inflammation due to impaired ROS production. Understanding the role of NCF1 could open doors to potential therapeutic strategies for enhancing host defense mechanisms against pathogens.