Explore the Potential with AI-Driven Innovation
The specialised, focused library is developed on demand with the most recent virtual screening and parameter assessment technology, guided by the Receptor.AI drug discovery platform. This approach exceeds the capabilities of traditional methods and offers compounds with higher activity, selectivity, and safety.
Our selection of compounds is from a large virtual library of over 60 billion molecules. The production and distribution of these compounds are managed by our partner Reaxense.
The library includes a list of the most promising modulators annotated with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Also, each compound is presented with its optimal docking poses, affinity scores, and activity scores, providing a comprehensive overview.
We employ our advanced, specialised process to create targeted libraries for receptors.
Fig. 1. The sreening workflow of Receptor.AI
This process includes extensive molecular simulations of the receptor in its native membrane environment, along with ensemble virtual screening that accounts for its conformational mobility. In the case of dimeric or oligomeric receptors, the entire functional complex is modelled, identifying potential binding pockets on and between the subunits to encompass all possible mechanisms of action.
Our library stands out due to several important features:
partner
Reaxense
upacc
P14784
UPID:
IL2RB_HUMAN
Alternative names:
High affinity IL-2 receptor subunit beta; Interleukin-15 receptor subunit beta; p70-75
Alternative UPACC:
P14784; B2R765
Background:
The Interleukin-2 receptor subunit beta, also known as High affinity IL-2 receptor subunit beta and Interleukin-15 receptor subunit beta, plays a pivotal role in the immune system. It is crucial for the receptor-mediated endocytosis and mitogenic signals transduction of IL2, and, in association with IL15RA, enhances neutrophil phagocytosis stimulated by IL15.
Therapeutic significance:
Linked to Immunodeficiency 63 with lymphoproliferation and autoimmunity, this protein's understanding could pave the way for innovative treatments targeting immune dysregulation and enhancing viral infection defenses.