Explore the Potential with AI-Driven Innovation
This comprehensive focused library is produced on demand with state-of-the-art virtual screening and parameter assessment technology driven by Receptor.AI drug discovery platform. This approach outperforms traditional methods and provides higher-quality compounds with superior activity, selectivity and safety.
The compounds are cherry-picked from the vast virtual chemical space of over 60B molecules. The synthesis and delivery of compounds is facilitated by our partner Reaxense.
The library features a range of promising modulators, each detailed with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Plus, each compound is presented with its ideal docking poses, affinity scores, and activity scores, ensuring a thorough insight.
We use our state-of-the-art dedicated workflow for designing focused libraries for enzymes.
Fig. 1. The sreening workflow of Receptor.AI
The method includes detailed molecular simulations of the catalytic and allosteric binding pockets, along with ensemble virtual screening that considers their conformational flexibility. In the design of modulators, structural changes induced by reaction intermediates are taken into account to enhance activity and selectivity.
Key features that set our library apart include:
partner
Reaxense
upacc
P15735
UPID:
PHKG2_HUMAN
Alternative names:
PSK-C3; Phosphorylase kinase subunit gamma-2
Alternative UPACC:
P15735; A8K0C7; B4DEB7; E9PEU3; P11800
Background:
The Phosphorylase b kinase gamma catalytic chain, liver/testis isoform, known as PSK-C3 or Phosphorylase kinase subunit gamma-2, plays a pivotal role in glycogen metabolism. It acts as the catalytic subunit of the phosphorylase b kinase (PHK), crucial for the neural and hormonal regulation of glycogen breakdown through the phosphorylation and activation of glycogen phosphorylase. This process is essential for energy release in cells.
Therapeutic significance:
Glycogen storage disease 9C, a metabolic disorder linked to mutations in the gene encoding this protein, highlights its clinical importance. The disease manifests with hepatomegaly, growth retardation, and liver dysfunction, among other symptoms. Understanding the role of Phosphorylase b kinase gamma catalytic chain could open doors to potential therapeutic strategies for managing this condition and possibly other glycogen storage diseases.