Explore the Potential with AI-Driven Innovation
This extensive focused library is tailor-made using the latest virtual screening and parameter assessment technology, operated by the Receptor.AI drug discovery platform. This technique is more effective than traditional methods, offering compounds with improved activity, selectivity, and safety.
We carefully select specific compounds from a vast collection of over 60 billion molecules in virtual chemical space. Our partner Reaxense helps in synthesizing and delivering these compounds.
The library includes a list of the most effective modulators, each annotated with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Furthermore, each compound is shown with its optimal docking poses, affinity scores, and activity scores, offering a detailed summary.
Our high-tech, dedicated method is applied to construct targeted libraries.
Fig. 1. The sreening workflow of Receptor.AI
Our methodology employs molecular simulations to explore a wide array of proteins, capturing their dynamic states both individually and within complexes. Through ensemble virtual screening, we address conformational mobility, uncovering binding sites within functional regions and remote allosteric locations. This thorough exploration ensures no potential mechanism of action is overlooked, aiming to discover novel therapeutic targets and lead compounds across an extensive spectrum of biological functions.
Our library distinguishes itself through several key aspects:
partner
Reaxense
upacc
P15880
UPID:
RS2_HUMAN
Alternative names:
40S ribosomal protein S2; 40S ribosomal protein S4; Protein LLRep3
Alternative UPACC:
P15880; B2R5G0; D3DU82; Q3MIB1
Background:
Small ribosomal subunit protein uS5, also known as 40S ribosomal protein S2 and S4, is a crucial component of the ribosome, facilitating protein synthesis within the cell. It plays a pivotal role in the assembly and function of the 40S ribosomal subunit, ensuring the accurate translation of mRNA into polypeptide chains. This protein is also involved in the nucleolar processing of pre-18S ribosomal RNA, a critical step in ribosome assembly.
Therapeutic significance:
Understanding the role of Small ribosomal subunit protein uS5 could open doors to potential therapeutic strategies. Its involvement in the fundamental process of protein synthesis and ribosome assembly highlights its potential as a target for interventions aimed at correcting protein synthesis disorders.