Explore the Potential with AI-Driven Innovation
The focused library is created on demand with the latest virtual screening and parameter assessment technology, supported by the Receptor.AI drug discovery platform. This method is more effective than traditional methods and results in higher-quality compounds with better activity, selectivity, and safety.
From a virtual chemical space containing more than 60 billion molecules, we precisely choose certain compounds. Our collaborator, Reaxense, aids in their synthesis and provision.
Contained in the library are leading modulators, each labelled with 38 ADME-Tox and 32 physicochemical and drug-likeness qualities. In addition, each compound is illustrated with its optimal docking poses, affinity scores, and activity scores, giving a complete picture.
Our top-notch dedicated system is used to design specialised libraries for enzymes.
Fig. 1. The sreening workflow of Receptor.AI
The procedure entails thorough molecular simulations of the catalytic and allosteric binding pockets, accompanied by ensemble virtual screening that factors in their conformational flexibility. When developing modulators, the structural modifications brought about by reaction intermediates are factored in to optimize activity and selectivity.
Our library stands out due to several important features:
partner
Reaxense
upacc
P16066
UPID:
ANPRA_HUMAN
Alternative names:
Atrial natriuretic peptide receptor type A; Guanylate cyclase A
Alternative UPACC:
P16066; B0ZBF0; Q5SR08; Q6P4Q3
Background:
Atrial natriuretic peptide receptor 1, also known as Guanylate cyclase A, is a key player in cardiovascular homeostasis. It serves as a receptor for atrial natriuretic peptide (ANP) and brain natriuretic peptide (BNP), which are crucial for regulating blood pressure and fluid balance. The receptor's activation triggers guanylate cyclase activity, leading to vasodilation.
Therapeutic significance:
Understanding the role of Atrial natriuretic peptide receptor 1 could open doors to potential therapeutic strategies. Its involvement in cardiovascular regulation makes it a promising target for treating hypertension and heart failure.