Explore the Potential with AI-Driven Innovation
The specialised, focused library is developed on demand with the most recent virtual screening and parameter assessment technology, guided by the Receptor.AI drug discovery platform. This approach exceeds the capabilities of traditional methods and offers compounds with higher activity, selectivity, and safety.
The compounds are cherry-picked from the vast virtual chemical space of over 60B molecules. The synthesis and delivery of compounds is facilitated by our partner Reaxense.
The library includes a list of the most promising modulators annotated with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Also, each compound is presented with its optimal docking poses, affinity scores, and activity scores, providing a comprehensive overview.
Our high-tech, dedicated method is applied to construct targeted libraries.
Fig. 1. The sreening workflow of Receptor.AI
Our methodology leverages molecular simulations to examine a vast array of proteins, capturing their dynamics in both isolated forms and in complexes with other proteins. Through ensemble virtual screening, we thoroughly account for the protein's conformational mobility, identifying critical binding sites within functional regions and distant allosteric locations. This detailed exploration ensures that we comprehensively assess every possible mechanism of action, with the objective of identifying novel therapeutic targets and lead compounds that span a wide spectrum of biological functions.
Our library stands out due to several important features:
partner
Reaxense
upacc
P17661
UPID:
DESM_HUMAN
Alternative names:
-
Alternative UPACC:
P17661; Q15787; Q549R7; Q549R8; Q549R9; Q8IZR1; Q8IZR6; Q8NES2; Q8NEU6; Q8TAC4; Q8TCX2; Q8TD99; Q9UHN5; Q9UJ80
Background:
Desmin, a muscle-specific type III intermediate filament, is pivotal in maintaining muscular structure and function. It interconnects Z-disks, forms myofibrils, and links them to the sarcolemmal cytoskeleton, nucleus, and mitochondria, providing strength during muscle activity. Desmin's association with detyrosinated tubulin-alpha chains suggests a role as a sarcomeric microtubule-anchoring protein.
Therapeutic significance:
Mutations in the DES gene, encoding Desmin, are linked to a spectrum of muscle and cardiac diseases, including myofibrillar myopathy, dilated cardiomyopathy, and neurogenic scapuloperoneal syndrome Kaeser type. Understanding Desmin's role could lead to targeted therapies for these conditions.