Explore the Potential with AI-Driven Innovation
This comprehensive focused library is produced on demand with state-of-the-art virtual screening and parameter assessment technology driven by Receptor.AI drug discovery platform. This approach outperforms traditional methods and provides higher-quality compounds with superior activity, selectivity and safety.
From a virtual chemical space containing more than 60 billion molecules, we precisely choose certain compounds. Our collaborator, Reaxense, aids in their synthesis and provision.
The library includes a list of the most promising modulators annotated with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Also, each compound is presented with its optimal docking poses, affinity scores, and activity scores, providing a comprehensive overview.
We use our state-of-the-art dedicated workflow for designing focused libraries for enzymes.
Fig. 1. The sreening workflow of Receptor.AI
This approach involves comprehensive molecular simulations of the catalytic and allosteric binding pockets and ensemble virtual screening that accounts for their conformational flexibility. In the case of designing modulators, the structural adjustments caused by reaction intermediates are considered to improve activity and selectivity.
Our library stands out due to several important features:
partner
Reaxense
upacc
P17844
UPID:
DDX5_HUMAN
Alternative names:
DEAD box protein 5; RNA helicase p68
Alternative UPACC:
P17844; B4DLW8; B5BU21; D3DU32; E7ETL9; O75681; Q53Y61
Background:
Probable ATP-dependent RNA helicase DDX5, also known as DEAD box protein 5 and RNA helicase p68, plays a pivotal role in various cellular processes. It is essential for the alternative regulation of pre-mRNA splicing, transcriptional regulation, and skeletal muscle differentiation. DDX5's RNA helicase activity, crucial for tau exon 10 inclusion, is stimulated by single-stranded RNA. It acts as a transcriptional coactivator for androgen receptor AR, p53/TP53, and RUNX2, while repressing transcription in a promoter-specific manner.
Therapeutic significance:
Understanding the role of Probable ATP-dependent RNA helicase DDX5 could open doors to potential therapeutic strategies.