Explore the Potential with AI-Driven Innovation
Our detailed focused library is generated on demand with advanced virtual screening and parameter assessment technology powered by the Receptor.AI drug discovery platform. This method surpasses traditional approaches, delivering compounds of better quality with enhanced activity, selectivity, and safety.
We pick out particular compounds from an extensive virtual database of more than 60 billion molecules. The preparation and shipment of these compounds are facilitated by our associate Reaxense.
In the library, a selection of top modulators is provided, each marked with 38 ADME-Tox and 32 parameters related to physicochemical properties and drug-likeness. Also, every compound comes with its best docking poses, affinity scores, and activity scores, providing a comprehensive overview.
We employ our advanced, specialised process to create targeted libraries for enzymes.
Fig. 1. The sreening workflow of Receptor.AI
It includes in-depth molecular simulations of both the catalytic and allosteric binding pockets, with ensemble virtual screening focusing on their conformational flexibility. For modulators, the process includes considering the structural shifts due to reaction intermediates to boost activity and selectivity.
Key features that set our library apart include:
partner
Reaxense
upacc
P19801
UPID:
AOC1_HUMAN
Alternative names:
Amiloride-binding protein 1; Amine oxidase copper domain-containing protein 1; Histaminase; Kidney amine oxidase
Alternative UPACC:
P19801; C9J690; Q16683; Q16684; Q56II4; Q6GU42
Background:
Amiloride-sensitive amine oxidase [copper-containing], also known as Amiloride-binding protein 1, Amine oxidase copper domain-containing protein 1, Histaminase, and Kidney amine oxidase, plays a crucial role in the degradation of biogenic amines such as putrescine, histamine, spermine, and spermidine. These compounds are pivotal in various physiological processes including allergic and immune responses, cell proliferation, tissue differentiation, tumor formation, and apoptosis.
Therapeutic significance:
Understanding the role of Amiloride-sensitive amine oxidase [copper-containing] could open doors to potential therapeutic strategies. Its involvement in the regulation of compounds critical to immune responses and cell proliferation highlights its potential as a target in treating diseases related to immune system dysregulation and cancer.