Explore the Potential with AI-Driven Innovation
This comprehensive focused library is produced on demand with state-of-the-art virtual screening and parameter assessment technology driven by Receptor.AI drug discovery platform. This approach outperforms traditional methods and provides higher-quality compounds with superior activity, selectivity and safety.
We pick out particular compounds from an extensive virtual database of more than 60 billion molecules. The preparation and shipment of these compounds are facilitated by our associate Reaxense.
The library includes a list of the most promising modulators annotated with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Also, each compound is presented with its optimal docking poses, affinity scores, and activity scores, providing a comprehensive overview.
We utilise our cutting-edge, exclusive workflow to develop focused libraries for enzymes.
Fig. 1. The sreening workflow of Receptor.AI
It includes comprehensive molecular simulations of the catalytic and allosteric binding pockets and the ensemble virtual screening accounting for their conformational mobility. In the case of designing modulators, the structural changes induced by reaction intermediates are taken into account to leverage activity and selectivity.
Key features that set our library apart include:
partner
Reaxense
upacc
P19961
UPID:
AMY2B_HUMAN
Alternative names:
1,4-alpha-D-glucan glucanohydrolase 2B; Carcinoid alpha-amylase
Alternative UPACC:
P19961; B3KTI1; B3KXB7; D3DT76; Q9UBH3
Background:
Alpha-amylase 2B, also known as 1,4-alpha-D-glucan glucanohydrolase 2B and Carcinoid alpha-amylase, plays a crucial role in the breakdown of starch into sugars. This enzyme is pivotal in the digestive process, facilitating the conversion of complex carbohydrates into simple sugars that can be absorbed by the body.
Therapeutic significance:
Understanding the role of Alpha-amylase 2B could open doors to potential therapeutic strategies. Its critical function in carbohydrate metabolism makes it a potential target for addressing metabolic disorders and improving digestive health.