Explore the Potential with AI-Driven Innovation
Our detailed focused library is generated on demand with advanced virtual screening and parameter assessment technology powered by the Receptor.AI drug discovery platform. This method surpasses traditional approaches, delivering compounds of better quality with enhanced activity, selectivity, and safety.
Our selection of compounds is from a large virtual library of over 60 billion molecules. The production and distribution of these compounds are managed by our partner Reaxense.
The library includes a list of the most effective modulators, each annotated with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Furthermore, each compound is shown with its optimal docking poses, affinity scores, and activity scores, offering a detailed summary.
We utilise our cutting-edge, exclusive workflow to develop focused libraries for enzymes.
Fig. 1. The sreening workflow of Receptor.AI
It includes comprehensive molecular simulations of the catalytic and allosteric binding pockets and the ensemble virtual screening accounting for their conformational mobility. In the case of designing modulators, the structural changes induced by reaction intermediates are taken into account to leverage activity and selectivity.
Our library is unique due to several crucial aspects:
partner
Reaxense
upacc
P20794
UPID:
MAK_HUMAN
Alternative names:
Male germ cell-associated kinase
Alternative UPACC:
P20794; F1T0K6; G1FL29; Q547D0; Q9NUH7
Background:
Serine/threonine-protein kinase MAK, also known as Male germ cell-associated kinase, plays a pivotal role in various cellular processes. It is essential for the regulation of ciliary length, crucial for photoreceptor survival, and involved in spermatogenesis. Additionally, MAK phosphorylates FZR1 in a cell cycle-dependent manner and contributes to chromosomal stability in prostate cancer cells.
Therapeutic significance:
MAK's involvement in Retinitis pigmentosa 62, a retinal dystrophy characterized by loss of photoreceptors and vision, highlights its potential as a therapeutic target. Understanding the role of Serine/threonine-protein kinase MAK could open doors to potential therapeutic strategies for this and related diseases.