Explore the Potential with AI-Driven Innovation
Our detailed focused library is generated on demand with advanced virtual screening and parameter assessment technology powered by the Receptor.AI drug discovery platform. This method surpasses traditional approaches, delivering compounds of better quality with enhanced activity, selectivity, and safety.
The compounds are cherry-picked from the vast virtual chemical space of over 60B molecules. The synthesis and delivery of compounds is facilitated by our partner Reaxense.
The library features a range of promising modulators, each detailed with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Plus, each compound is presented with its ideal docking poses, affinity scores, and activity scores, ensuring a thorough insight.
Our high-tech, dedicated method is applied to construct targeted libraries for receptors.
Fig. 1. The sreening workflow of Receptor.AI
This process includes extensive molecular simulations of the receptor in its native membrane environment, along with ensemble virtual screening that accounts for its conformational mobility. In the case of dimeric or oligomeric receptors, the entire functional complex is modelled, identifying potential binding pockets on and between the subunits to encompass all possible mechanisms of action.
Our library distinguishes itself through several key aspects:
partner
Reaxense
upacc
P21453
UPID:
S1PR1_HUMAN
Alternative names:
Endothelial differentiation G-protein coupled receptor 1; Sphingosine 1-phosphate receptor Edg-1
Alternative UPACC:
P21453; D3DT66; Q9BYY4; Q9NYN8
Background:
The Sphingosine 1-phosphate receptor 1 (S1P1), also known as Endothelial differentiation G-protein coupled receptor 1, plays a pivotal role in cell migration, heart development, angiogenesis, and immune function. It operates through G(i) proteins, activating several key pathways including RAC1, SRC, PTK2/FAK1, and MAP kinases. Its involvement in the reorganization of the actin cytoskeleton and lamellipodia formation is crucial for cell movement and response to sphingosine kinase SPHK1 activity.
Therapeutic significance:
Understanding the role of Sphingosine 1-phosphate receptor 1 could open doors to potential therapeutic strategies. Its critical functions in heart development, immune cell migration, and vascular maturation highlight its potential as a target in treating cardiovascular diseases, immune disorders, and promoting wound healing and tissue regeneration.