Explore the Potential with AI-Driven Innovation
The focused library is created on demand with the latest virtual screening and parameter assessment technology, supported by the Receptor.AI drug discovery platform. This method is more effective than traditional methods and results in higher-quality compounds with better activity, selectivity, and safety.
The compounds are cherry-picked from the vast virtual chemical space of over 60B molecules. The synthesis and delivery of compounds is facilitated by our partner Reaxense.
The library features a range of promising modulators, each detailed with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Plus, each compound is presented with its ideal docking poses, affinity scores, and activity scores, ensuring a thorough insight.
We use our state-of-the-art dedicated workflow for designing focused libraries for receptors.
Fig. 1. The sreening workflow of Receptor.AI
This process includes extensive molecular simulations of the receptor in its native membrane environment, along with ensemble virtual screening that accounts for its conformational mobility. In the case of dimeric or oligomeric receptors, the entire functional complex is modelled, identifying potential binding pockets on and between the subunits to encompass all possible mechanisms of action.
Our library is unique due to several crucial aspects:
partner
Reaxense
upacc
P21728
UPID:
DRD1_HUMAN
Alternative names:
Dopamine D1 receptor
Alternative UPACC:
P21728; B2RA44; Q4QRJ0
Background:
The D(1A) dopamine receptor, also known as the Dopamine D1 receptor, plays a pivotal role in the central nervous system. Its activity is mediated by G proteins which activate adenylyl cyclase, a key enzyme in the production of cyclic AMP. This receptor is crucial for modulating neurotransmission and cognitive processes.
Therapeutic significance:
Understanding the role of the D(1A) dopamine receptor could open doors to potential therapeutic strategies. Its involvement in neurotransmission and cognitive functions highlights its potential as a target for treating neurological disorders.