Explore the Potential with AI-Driven Innovation
Our detailed focused library is generated on demand with advanced virtual screening and parameter assessment technology powered by the Receptor.AI drug discovery platform. This method surpasses traditional approaches, delivering compounds of better quality with enhanced activity, selectivity, and safety.
We pick out particular compounds from an extensive virtual database of more than 60 billion molecules. The preparation and shipment of these compounds are facilitated by our associate Reaxense.
Contained in the library are leading modulators, each labelled with 38 ADME-Tox and 32 physicochemical and drug-likeness qualities. In addition, each compound is illustrated with its optimal docking poses, affinity scores, and activity scores, giving a complete picture.
We utilise our cutting-edge, exclusive workflow to develop focused libraries.
Fig. 1. The sreening workflow of Receptor.AI
By deploying molecular simulations, our approach comprehensively covers a broad array of proteins, tracking their flexibility and dynamics individually and within complexes. Ensemble virtual screening is utilised to take into account conformational dynamics, identifying pivotal binding sites located within functional regions and at allosteric locations. This thorough exploration ensures that every conceivable mechanism of action is considered, aiming to identify new therapeutic targets and advance lead compounds throughout a vast spectrum of biological functions.
Several key aspects differentiate our library:
partner
Reaxense
upacc
P21754
UPID:
ZP3_HUMAN
Alternative names:
Sperm receptor; ZP3A/ZP3B; Zona pellucida glycoprotein 3; Zona pellucida protein C
Alternative UPACC:
P21754; Q06633; Q29RW0
Background:
Zona pellucida sperm-binding protein 3, also known as ZP3, plays a pivotal role in fertilization. It is a key component of the zona pellucida, an extracellular matrix that surrounds oocytes. ZP3 is crucial for sperm binding, triggering the acrosome reaction, and preventing polyspermy. This protein is one of the glycoproteins, including ZP1, ZP2, and ZP4, that compose the zona pellucida.
Therapeutic significance:
ZP3's involvement in oocyte/zygote/embryo maturation arrest 3, a disorder leading to infertility due to abnormal oocytes, highlights its therapeutic potential. Understanding the role of Zona pellucida sperm-binding protein 3 could open doors to potential therapeutic strategies for treating infertility.