Explore the Potential with AI-Driven Innovation
The focused library is created on demand with the latest virtual screening and parameter assessment technology, supported by the Receptor.AI drug discovery platform. This method is more effective than traditional methods and results in higher-quality compounds with better activity, selectivity, and safety.
The compounds are cherry-picked from the vast virtual chemical space of over 60B molecules. The synthesis and delivery of compounds is facilitated by our partner Reaxense.
The library features a range of promising modulators, each detailed with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Plus, each compound is presented with its ideal docking poses, affinity scores, and activity scores, ensuring a thorough insight.
Our top-notch dedicated system is used to design specialised libraries.
Fig. 1. The sreening workflow of Receptor.AI
Utilising molecular simulations, our approach thoroughly examines a wide array of proteins, tracking their conformational changes individually and within complexes. Ensemble virtual screening enables us to address conformational flexibility, revealing essential binding sites at functional regions and allosteric locations. Our rigorous analysis guarantees that no potential mechanism of action is overlooked, aiming to uncover new therapeutic targets and lead compounds across diverse biological functions.
Our library distinguishes itself through several key aspects:
partner
Reaxense
upacc
P23435
UPID:
CBLN1_HUMAN
Alternative names:
Precerebellin
Alternative UPACC:
P23435; B2RAN9; P02682; Q52M09
Background:
Cerebellin-1, also known as Precerebellin, plays a pivotal role in synapse integrity and synaptic plasticity. It is crucial for the matching and maintenance of pre- and post-synaptic elements, establishing climbing fiber-Purkinje cell innervation, and inducing long-term depression at parallel fiber-Purkinje cell synapses. It functions as a synaptic organizer, influencing both pre- and post-synaptic components, and is essential for the long-term maintenance of excitatory synapses.
Therapeutic significance:
Understanding the role of Cerebellin-1 could open doors to potential therapeutic strategies.