Explore the Potential with AI-Driven Innovation
The focused library is created on demand with the latest virtual screening and parameter assessment technology, supported by the Receptor.AI drug discovery platform. This method is more effective than traditional methods and results in higher-quality compounds with better activity, selectivity, and safety.
From a virtual chemical space containing more than 60 billion molecules, we precisely choose certain compounds. Our collaborator, Reaxense, aids in their synthesis and provision.
The library features a range of promising modulators, each detailed with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Plus, each compound is presented with its ideal docking poses, affinity scores, and activity scores, ensuring a thorough insight.
We use our state-of-the-art dedicated workflow for designing focused libraries for enzymes.
Fig. 1. The sreening workflow of Receptor.AI
This approach involves comprehensive molecular simulations of the catalytic and allosteric binding pockets and ensemble virtual screening that accounts for their conformational flexibility. In the case of designing modulators, the structural adjustments caused by reaction intermediates are considered to improve activity and selectivity.
Several key aspects differentiate our library:
partner
Reaxense
upacc
P23471
UPID:
PTPRZ_HUMAN
Alternative names:
Protein-tyrosine phosphatase receptor type Z polypeptide 1; Protein-tyrosine phosphatase receptor type Z polypeptide 2; R-PTP-zeta-2
Alternative UPACC:
P23471; A4D0W5; C9JFM0; O76043; Q9UDR6
Background:
Receptor-type tyrosine-protein phosphatase zeta, known by its alternative names such as Protein-tyrosine phosphatase receptor type Z polypeptide 1 and 2, and R-PTP-zeta-2, plays a crucial role in the development of the central nervous system. It is instrumental in regulating the proliferation of oligodendrocyte precursor cells in the embryonic spinal cord and is essential for their differentiation into mature oligodendrocytes that are responsible for myelination.
Therapeutic significance:
Understanding the role of Receptor-type tyrosine-protein phosphatase zeta could open doors to potential therapeutic strategies. Its involvement in oligodendrocyte differentiation and protection against apoptosis highlights its potential as a target in treating demyelinating diseases and enhancing neural regeneration.