Explore the Potential with AI-Driven Innovation
This extensive focused library is tailor-made using the latest virtual screening and parameter assessment technology, operated by the Receptor.AI drug discovery platform. This technique is more effective than traditional methods, offering compounds with improved activity, selectivity, and safety.
Our selection of compounds is from a large virtual library of over 60 billion molecules. The production and distribution of these compounds are managed by our partner Reaxense.
The library includes a list of the most promising modulators annotated with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Also, each compound is presented with its optimal docking poses, affinity scores, and activity scores, providing a comprehensive overview.
We utilise our cutting-edge, exclusive workflow to develop focused libraries for enzymes.
Fig. 1. The sreening workflow of Receptor.AI
The procedure entails thorough molecular simulations of the catalytic and allosteric binding pockets, accompanied by ensemble virtual screening that factors in their conformational flexibility. When developing modulators, the structural modifications brought about by reaction intermediates are factored in to optimize activity and selectivity.
Our library stands out due to several important features:
partner
Reaxense
upacc
P24158
UPID:
PRTN3_HUMAN
Alternative names:
AGP7; C-ANCA antigen; Leukocyte proteinase 3; Neutrophil proteinase 4; P29; Wegener autoantigen
Alternative UPACC:
P24158; P15637; P18078; Q4VB08; Q4VB09; Q6LBM7; Q6LBN2; Q9UD25; Q9UQD8
Background:
Myeloblastin, also known as AGP7, C-ANCA antigen, Leukocyte proteinase 3, and other names, is a serine protease with a broad substrate range, including elastin, fibronectin, and various collagen types. It plays a pivotal role in degrading extracellular matrix components, enhancing endothelial cell barrier function, and facilitating neutrophil transendothelial migration.
Therapeutic significance:
Understanding the role of Myeloblastin could open doors to potential therapeutic strategies. Its involvement in modulating vascular integrity and immune response highlights its potential as a target for treating inflammatory and vascular diseases.