Explore the Potential with AI-Driven Innovation
The focused library is created on demand with the latest virtual screening and parameter assessment technology, supported by the Receptor.AI drug discovery platform. This method is more effective than traditional methods and results in higher-quality compounds with better activity, selectivity, and safety.
We pick out particular compounds from an extensive virtual database of more than 60 billion molecules. The preparation and shipment of these compounds are facilitated by our associate Reaxense.
Contained in the library are leading modulators, each labelled with 38 ADME-Tox and 32 physicochemical and drug-likeness qualities. In addition, each compound is illustrated with its optimal docking poses, affinity scores, and activity scores, giving a complete picture.
We use our state-of-the-art dedicated workflow for designing focused libraries for enzymes.
Fig. 1. The sreening workflow of Receptor.AI
It includes comprehensive molecular simulations of the catalytic and allosteric binding pockets and the ensemble virtual screening accounting for their conformational mobility. In the case of designing modulators, the structural changes induced by reaction intermediates are taken into account to leverage activity and selectivity.
Our library distinguishes itself through several key aspects:
partner
Reaxense
upacc
P24928
UPID:
RPB1_HUMAN
Alternative names:
DNA-directed RNA polymerase II subunit A; DNA-directed RNA polymerase III largest subunit; RNA-directed RNA polymerase II subunit RPB1
Alternative UPACC:
P24928; A6NN93; B9EH88; Q6NX41
Background:
DNA-directed RNA polymerase II subunit RPB1 plays a pivotal role in transcribing DNA into RNA, utilizing ribonucleoside triphosphates as substrates. It's the largest component of RNA polymerase II, essential for synthesizing mRNA precursors and various non-coding RNAs. RPB1's dynamic structure, including a large cleft and a clamp element, facilitates the transcription process by moving relative to the DNA template.
Therapeutic significance:
The protein's involvement in neurodevelopmental disorder with hypotonia and variable intellectual and behavioral abnormalities highlights its potential as a target for therapeutic intervention. Understanding RPB1's role could open doors to novel strategies for treating such neurodevelopmental disorders.