Explore the Potential with AI-Driven Innovation
This comprehensive focused library is produced on demand with state-of-the-art virtual screening and parameter assessment technology driven by Receptor.AI drug discovery platform. This approach outperforms traditional methods and provides higher-quality compounds with superior activity, selectivity and safety.
From a virtual chemical space containing more than 60 billion molecules, we precisely choose certain compounds. Our collaborator, Reaxense, aids in their synthesis and provision.
The library features a range of promising modulators, each detailed with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Plus, each compound is presented with its ideal docking poses, affinity scores, and activity scores, ensuring a thorough insight.
We utilise our cutting-edge, exclusive workflow to develop focused libraries for receptors.
Fig. 1. The sreening workflow of Receptor.AI
It features thorough molecular simulations of the receptor within its native membrane environment, complemented by ensemble virtual screening that considers its conformational mobility. For dimeric or oligomeric receptors, the full functional complex is constructed, and tentative binding sites are determined on and between the subunits to cover the entire spectrum of potential mechanisms of action.
Key features that set our library apart include:
partner
Reaxense
upacc
P25106
UPID:
ACKR3_HUMAN
Alternative names:
C-X-C chemokine receptor type 7; Chemokine orphan receptor 1; G-protein coupled receptor 159; G-protein coupled receptor RDC1 homolog
Alternative UPACC:
P25106; A8K6J4; Q53RV4; Q8NE10; Q92938; Q92986
Background:
Atypical chemokine receptor 3 (ACKR3), also known as CXCR7, plays a pivotal role in chemokine regulation, acting through high-affinity binding to chemokines CXCL11 and CXCL12/SDF1. Unlike typical receptors, ACKR3 does not initiate classic G-protein signal cascades but instead sequesters chemokines, leading to their degradation or transcytosis. This unique mechanism influences various cellular responses, including MAPK signaling pathway activation, cell growth, and survival.
Therapeutic significance:
ACKR3's involvement in diseases such as Oculomotor-abducens synkinesis, and its role in glioma cell resistance to apoptosis, highlights its potential as a therapeutic target. Understanding the role of Atypical chemokine receptor 3 could open doors to potential therapeutic strategies, especially in treating neurological disorders and combating glioma cell proliferation.