Explore the Potential with AI-Driven Innovation
The focused library is created on demand with the latest virtual screening and parameter assessment technology, supported by the Receptor.AI drug discovery platform. This method is more effective than traditional methods and results in higher-quality compounds with better activity, selectivity, and safety.
The compounds are cherry-picked from the vast virtual chemical space of over 60B molecules. The synthesis and delivery of compounds is facilitated by our partner Reaxense.
The library includes a list of the most promising modulators annotated with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Also, each compound is presented with its optimal docking poses, affinity scores, and activity scores, providing a comprehensive overview.
Our high-tech, dedicated method is applied to construct targeted libraries.
Fig. 1. The sreening workflow of Receptor.AI
Our methodology employs molecular simulations to explore a wide array of proteins, capturing their dynamic states both individually and within complexes. Through ensemble virtual screening, we address conformational mobility, uncovering binding sites within functional regions and remote allosteric locations. This thorough exploration ensures no potential mechanism of action is overlooked, aiming to discover novel therapeutic targets and lead compounds across an extensive spectrum of biological functions.
Our library stands out due to several important features:
partner
Reaxense
upacc
P25788
UPID:
PSA3_HUMAN
Alternative names:
Macropain subunit C8; Multicatalytic endopeptidase complex subunit C8; Proteasome component C8
Alternative UPACC:
P25788; B2RCK6; Q86U83; Q8N1D8; Q9BS70
Background:
Proteasome subunit alpha type-3, also known as Macropain subunit C8, plays a pivotal role in intracellular protein degradation. It is a core component of the 20S proteasome complex, essential for cellular homeostasis by degrading misfolded or damaged proteins. This protein is involved in ATP-dependent and independent pathways, crucial for processes like spermatogenesis and antigen presentation.
Therapeutic significance:
Understanding the role of Proteasome subunit alpha type-3 could open doors to potential therapeutic strategies.