Explore the Potential with AI-Driven Innovation
This extensive focused library is tailor-made using the latest virtual screening and parameter assessment technology, operated by the Receptor.AI drug discovery platform. This technique is more effective than traditional methods, offering compounds with improved activity, selectivity, and safety.
Our selection of compounds is from a large virtual library of over 60 billion molecules. The production and distribution of these compounds are managed by our partner Reaxense.
The library includes a list of the most effective modulators, each annotated with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Furthermore, each compound is shown with its optimal docking poses, affinity scores, and activity scores, offering a detailed summary.
Our top-notch dedicated system is used to design specialised libraries.
Fig. 1. The sreening workflow of Receptor.AI
Our strategy employs molecular simulations to explore an extensive range of proteins, capturing their dynamics both individually and within complexes with other proteins. Through ensemble virtual screening, we address proteins' conformational mobility, uncovering key binding sites at both functional regions and remote allosteric locations. This comprehensive investigation ensures a thorough assessment of all potential mechanisms of action, with the goal of discovering innovative therapeutic targets and lead molecules across across diverse biological functions.
Key features that set our library apart include:
partner
Reaxense
upacc
P26715
UPID:
NKG2A_HUMAN
Alternative names:
CD159 antigen-like family member A; NK cell receptor A; NKG2-A/B-activating NK receptor
Alternative UPACC:
P26715
Background:
The NKG2-A/NKG2-B type II integral membrane protein, also known as CD159 antigen-like family member A, plays a pivotal role in immune regulation. It functions as an immune inhibitory receptor, distinguishing between self and non-self by recognizing non-classical MHC class Ib molecule HLA-E loaded with self-peptides. This mechanism enables cytotoxic cells to monitor healthy cells' MHC class I molecule expression, ensuring self-tolerance and preventing autoimmunity.
Therapeutic significance:
Understanding the role of NKG2-A/NKG2-B type II integral membrane protein could open doors to potential therapeutic strategies. Its involvement in immune regulation and self-nonself discrimination highlights its potential as a target for modulating immune responses in various diseases.