Explore the Potential with AI-Driven Innovation
This extensive focused library is tailor-made using the latest virtual screening and parameter assessment technology, operated by the Receptor.AI drug discovery platform. This technique is more effective than traditional methods, offering compounds with improved activity, selectivity, and safety.
The compounds are cherry-picked from the vast virtual chemical space of over 60B molecules. The synthesis and delivery of compounds is facilitated by our partner Reaxense.
The library features a range of promising modulators, each detailed with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Plus, each compound is presented with its ideal docking poses, affinity scores, and activity scores, ensuring a thorough insight.
We utilise our cutting-edge, exclusive workflow to develop focused libraries for protein-protein interfaces.
Fig. 1. The sreening workflow of Receptor.AI
It includes extensive molecular simulations of the target alone and in complex with its most relevant partner proteins, followed by ensemble virtual screening that accounts for conformational mobility in free and bound forms. The tentative binding pockets are considered on the protein-protein interface itself and in remote allosteric locations in order to cover the whole spectrum of possible mechanisms of action.
Our library distinguishes itself through several key aspects:
partner
Reaxense
upacc
P28799
UPID:
GRN_HUMAN
Alternative names:
Acrogranin; Epithelin precursor; Glycoprotein of 88 Kda; Granulin precursor; PC cell-derived growth factor; Proepithelin
Alternative UPACC:
P28799; D3DX55; P23781; P23782; P23783; P23784; Q53HQ8; Q53Y88; Q540U8; Q9BWE7; Q9H8S1; Q9UCH0
Background:
Progranulin, known by alternative names such as Acrogranin and Granulin precursor, is a secreted protein pivotal in lysosomal function, inflammation, and cell proliferation. It regulates protein trafficking to lysosomes, enhances lysosomal enzyme activity, and is crucial in wound healing and cell growth. Progranulin's interaction with CTSD stabilizes it, maintaining its peptidase activity.
Therapeutic significance:
Linked to diseases like Ubiquitin-positive frontotemporal dementia and neuronal ceroid lipofuscinosis, Progranulin's role in neurodegeneration highlights its therapeutic potential. Understanding Progranulin's functions could lead to breakthroughs in treating these debilitating conditions.